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Ann Thorac Surg 94(4):1104-11

Estrogens could positively affect dopamine neurotransmission by reducing the expression of catechol-O-methyltransferase (COMT), the enzyme responsible for dopamine degradation (Jiang et al., 2003)

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The effect on appetite is partially mediated by the activation of neuropeptide Y (NPY) release in the hypothalamus